Reference values

After 1 February 2019 we have standardized our WCX-TOF MS assay with our 2^nd reference material that is value assigned by a primary reference material (1,2).

Here you find:

•  Our reference ranges for hepcidin concentrations  that we reported before 1 February 2019
•  Our standardized reference ranges for hepcidin concentrations that we reported after 1 February 2019.

 

Reference ranges for hepcidin concentrations  that we reported before 1 February 2019

Age- and sex-stratified reference ranges of serum hepcidin-25 concentration in a large, well-phenotyped, sample of the general population (n = 2998), including the reference [hepcidin/ferritin] and [transferrin saturation/hepcidin] ratios, which are important for the clinical interpretation of measured hepcidin concentrations.

Reference values WCX-TOF MS (download)

 

Reference ranges of serum hepcidin-25 concentration and [hepcidin/ferritin] ratio determined in a population of healthy children, aged 6 months to 3 years old.

Reference values WCX-TOF MS children 6mo to 3yr (download)

 

Reference ranges for serum hepcidin-25 in specified time periods during pregnancy.

Reference values WCX-TOF MS pregnancy (download)

 

Reference ranges for hepcidin concentrations  that we reported after 1 February 2019

Age- and sex-stratified reference ranges of serum hepcidin-25 concentration in a large, well-phenotyped, sample of the general population (n = 2998), including the reference [hepcidin/ferritin] and [transferrin saturation/hepcidin] ratios, which are important for the clinical interpretation of measured hepcidin concentrations.

Reference values WCX-TOF MS standardized (download)

 

Reference ranges of serum hepcidin-25 concentration and [hepcidin/ferritin] ratio that were determined in a population of healthy children, aged 6 months to 3 years old.

Reference values WCX-TOF MS children 6mo to 3yr standardized (download)

 

Age and sex-stratified reference ranges of serum hepcidin-25 concentration that were determined in a population of healthy children of all ages, including the reference ranges for [hepcidin/ferritin] and [transferrin saturation/hepcidin] ratios.

Reference values WCX-TOF MS children all ages standardized (download)

 

Reference ranges for serum hepcidin-25 in specified time periods during pregnancy.

Reference values WCX-TOF MS pregnancy standardized (download)

 

Reference:

 

1. Diepeveen LE, Laarakkers CMM, Martos G, Pawlak ME, Uğuz FF, Verberne KESA, van Swelm RPL, Klaver S, de Haan AFJ, Pitts KR, Bansal SS, Abbas IM, Fillet M, Lefebvre T, Geurts-Moespot AJ, Girelli D, Castagna A, Herkert M, Itkonen O, Olbina G, Tomosugi N, Westerman ME, Delatour V, Weykamp CW, Swinkels DW. Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference material. Clin Chem Lab Med. 2019;27;57(6):864-872.
2. Aune ET, Diepeveen LE, Laarakkers CM, Klaver S, Armitage AE, Bansal S, Chen M, Fillet M, Han H, Herkert M, Itkonen O, van de Kerkhof D, Krygier A, Lefebvre T, Neyer P, Rieke M, Tomosugi N, Weykamp CW, Swinkels DW.Optimizing hepcidin measurement with a proficiency test framework and standardization improvement.  Clin Chem Lab Med. 2020, ahead of print